Activity/Stability of Human Pepsin: Implications for Reflux Attributed Laryngeal Disease

@article{Johnston2007ActivityStabilityOH,
  title={Activity/Stability of Human Pepsin: Implications for Reflux Attributed Laryngeal Disease},
  author={Nikki Johnston and Peter William Dettmar and Bimjhana Bishwokarma and Mark O. Lively and James A. Koufman},
  journal={The Laryngoscope},
  year={2007},
  volume={117}
}
Objectives/Hypothesis: Exposure of laryngeal epithelia to pepsin during extra‐esophageal reflux causes depletion of laryngeal protective proteins, carbonic anhydrase isoenzyme III (CAIII), and squamous epithelial stress protein Sep70. The first objective of this study was to determine whether pepsin has to be enzymatically active to deplete these proteins. The second objective was to investigate the effect of pH on the activity and stability of human pepsin 3b under conditions that might be… 
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TLDR
A role for refluxed pepsin in the promotion of epithelial proliferation and carcinogenesis of the larynx and pharynx is supported.
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Biomarkers and laryngopharyngeal reflux
Abstract Laryngopharyngeal reflux is a controversial but increasingly made diagnosis used in patients with a collection of often non-specific laryngeal symptoms. It is a clinical diagnosis, and its…
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References

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TLDR
The objective was to investigate the potential use of pepsin and carbonic anhydrase isoenzyme III (CA‐III) as diagnostic markers for laryngopharyngeal reflux disease.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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