Activities of tobramycin and polymyxin E against Pseudomonas aeruginosa biofilm-coated medical grade endotracheal tubes.

@article{Tarquinio2014ActivitiesOT,
  title={Activities of tobramycin and polymyxin E against Pseudomonas aeruginosa biofilm-coated medical grade endotracheal tubes.},
  author={Keiko M. Tarquinio and Kelsey Confreda and James Shurko and Kerry L LaPlante},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 3},
  pages={
          1723-9
        }
}
Indwelling medical devices have become a major source of nosocomial infections, especially Pseudomonas aeruginosa infections, which remain the most common cause of ventilator-associated pneumonia (VAP) in neonates and children. Using medical grade polyvinyl chloride endotracheal tubes (ETTs), the activity of tobramycin and polymyxin E was quantified in a simulated prevention and treatment static time-kill model using biofilm-forming P. aeruginosa. The model simulated three clinical conditions… CONTINUE READING

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