Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease

  title={Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease},
  author={M. Bigl and M. Br{\"u}ckner and T. Arendt and V. Bigl and K. Eschrich},
  journal={Journal of Neural Transmission},
  • M. Bigl, M. Brückner, +2 authors K. Eschrich
  • Published 1999
  • Medicine, Biology
  • Journal of Neural Transmission
  • Summary. The activities of hexokinase, aldolase, pyruvate kinase, lactate dehydrogenase and glucose 6-phosphate dehydrogenase were determined in brains of patients with Alzheimer's disease (AD) and in age matched controls. For pyruvate kinase and lactate dehydrogenase a significant increase in specific activity was found in frontal and temporal cortex of AD brains, while the activities of aldolase and hexokinase are not changed. Glucose 6-phosphate dehydrogenase activity was significantly… CONTINUE READING
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