Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease

@article{Bigl1999ActivitiesOK,
  title={Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease},
  author={Marina Bigl and Martina K. Br{\"u}ckner and Th. Arendt and Volker Bigl and Klaus Eschrich},
  journal={Journal of Neural Transmission},
  year={1999},
  volume={106},
  pages={499-511}
}
The activities of hexokinase, aldolase, pyruvate kinase, lactate dehydrogenase and glucose 6-phosphate dehydrogenase were determined in brains of patients with Alzheimer's disease (AD) and in age matched controls. For pyruvate kinase and lactate dehydrogenase a significant increase in specific activity was found in frontal and temporal cortex of AD brains, while the activities of aldolase and hexokinase are not changed. Glucose 6-phosphate dehydrogenase activity was significantly reduced in… CONTINUE READING
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