Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism

  title={Activities of extract and constituents of Banisteriopsis caapi relevant to parkinsonism},
  author={M. J. Schwarz and Peter J Houghton and Sarah Rose and Peter Jenner and A D Lees},
  journal={Pharmacology Biochemistry and Behavior},

Is Ayahuasca a Potential Ethnic Plant for the Treatment of ParkinsonâÂÂs Disease?

Ayahuasca extract due its strong inhibitory effect on MAO A activity and more powerful inhibition of MAO B, and absence of toxicity could be used as an alternative or complementary therapy for the treatment of Parkinson´s disease.

Alkaloids of Peganum harmala L. and their Pharmacological Activity

Peganum harmala L. contains 17 alkaloids of quinazoline and indole structure types. Of these, harmaline, harmine, harmalol and L-peganin (vazicin) are pharmacologically active. It was established

Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells

The results suggest that the compounds found in B. caapi extract have anti-inflammatory potential that could be explored for the development of treatments for neurodegenerative diseases.

Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson’s Disease Model

A series of new multifunctional anti-Parkinson’s compounds are designed and synthesized which can protect cerebral granular neurons from 1-methyl-4-phenylpyridinium (MPP+) insult, scavenge free radicals, and inhibit monoamine oxidase (MAO)/cholinesterase (ChE) activities, and MT-20R exhibited the most potent MAO-B inhibition both in vitro and in vivo.

Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans

A systematic literature review using the PubMed database found five animal studies and five observational studies of regular ayahuasca consumers that showed improvement of biochemical or behavioral parameters related to drug-induced disorders.

Herbal Natural Products As a Source of Monoamine Oxidase Inhibitors: A Review

The pharmacological effects on the Central Nervous System of some plant extracts and their isolated chemical components due to their monoamine oxidase (MAO) activity are dealt with.



Pharmacokinetics of Hoasca alkaloids in healthy humans.

Banisterine and Parkinson's disease.

The story of banisterine is reviewed because it was the first MAO inhibitor to be used in parkinsonism, and illustrates the historical role of psychoactive drugs in the development of effective therapies, and in elucidating the pathophysiology of PD.