Activities of beta-lactam antibiotics against Escherichia coli strains producing extended-spectrum beta-lactamases.

@article{Jacoby1990ActivitiesOB,
  title={Activities of beta-lactam antibiotics against Escherichia coli strains producing extended-spectrum beta-lactamases.},
  author={George A. Jacoby and Isabel Carreras},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 5},
  pages={
          858-62
        }
}
Seven extended-spectrum beta-lactamases related to TEM and four enzymes derived from SHV-1 were transferred to a common Escherichia coli host so that the activity of a variety of beta-lactams could be tested in a uniform genetic environment. For most derivatives, penicillinase activity was 10% or less than that of strains making TEM-1, TEM-2, or SHV-1 beta-lactamase, suggesting that reduced catalytic efficiency accompanied the broader substrate spectrum. Despite this deficit, resistance to… CONTINUE READING

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