Activities of UDP-glucuronyltransferase ,-glucuronidase and deiodinase types I and II in hyper-and hypothyroid rats

We have investigated the hypothesis that uridine 5 diphosphate (UDP)-glucuronyltransferases (UGTs) and -glucuronidase are jointly involved in a mechanism for the storage and mobilization of iodothyronine metabolites in liver, kidney, heart and brain. Specifically, we predicted UGT activities to decrease and increase respectively, and -glucuronidase activity… (More)