Activities and regulation of peptidoglycan synthases

  title={Activities and regulation of peptidoglycan synthases},
  author={Alexander J F Egan and Jacob Biboy and Inge L Van't Veer and Eefjan Breukink and Waldemar Vollmer},
  booktitle={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
Peptidoglycan (PG) is an essential component in the cell wall of nearly all bacteria, forming a continuous, mesh-like structure, called the sacculus, around the cytoplasmic membrane to protect the cell from bursting by its turgor. Although PG synthases, the penicillin-binding proteins (PBPs), have been studied for 70 years, useful in vitro assays for measuring their activities were established only recently, and these provided the first insights into the regulation of these enzymes. Here, we… CONTINUE READING
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