Activities and Ultrastructural Effects of Antifungal Combinations against Simulated Candida Endocardial Vegetations

@article{Pai2008ActivitiesAU,
  title={Activities and Ultrastructural Effects of Antifungal Combinations against Simulated Candida Endocardial Vegetations},
  author={Manjunath P. Pai and Marie L Samples and Renee C. Mercier and Michael N Spilde},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2008},
  volume={52},
  pages={2367 - 2376}
}
ABSTRACT In vitro pharmacodynamic model (PDM) simulation of serum antifungal concentrations may predict the value of combination antifungal regimens against Candida sp. endocarditis. We investigated the effects of combinations of flucytosine (5FC), micafungin (Mica), and voriconazole (Vor) against Candida-infected human platelet-fibrin clots, used as simulated endocardial vegetations (SEVs). Single clinical bloodstream isolates of Candida albicans, Candida glabrata, Candida parapsilosis, and… Expand
Antifungal Combinations against Simulated Candida albicans Endocardial Vegetations
  • M. Pai
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2009
TLDR
The in vitro effects of flucytosine, liposomal amphotericin B, and micafungin combinations against two Candida albicans strains that simulated 24-hour-old endocardial vegetations were studied and Mica was superior to 5FC or L-AmB. Expand
[Scientific evidence supporting the use of micafungin in the treatment of invasive candidiasis].
TLDR
Micafungin is a dose-dependent candidacidal agent with excellent in vitro efficacy against most Candida spp. Expand
Evidencias científicas que respaldan el uso de micafungina en el tratamiento de la candidiasis invasora
TLDR
Micafungin is a dose-dependent candidacidal agent with excellent in vitro efficacy against most Candida spp. Expand
Brucella melitensis Endocarditis Combined With Candida albicans in a Patient With Prosthetic Valves
TLDR
C. albicans may become an additional causative agent of endocarditis because of extensive use of antibiotics and presence of deterioration, and a relapsing fever should alert the clinicians about this possibility. Expand
Anti-Candida-biofilm activity of micafungin is attenuated by voriconazole but restored by pharmacological inhibition of Hsp90-related stress responses.
TLDR
In vitro evaluation of the efficacy of a voriconazole-micafungin combination against Candida albicans and the mechanism of antagonism using inhibitors of Hsp90 and its effectors suggests that Hsp 90-related stress responses are involved in the antagonism. Expand
Chapter 14 Antifungals : Mechanism of Action and Drug Resistance
There are currently few antifungals in use which show efficacy against fungal diseases. These antifungals mostly target specific components of fungal plasma membrane or its biosynthetic pathways.Expand
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TLDR
This chapter reviews the mechanism of action of flucytosine, its resistance mechanisms, as well as the utility of combining it with other antifungal agents and a "rebirth" of this agent as a useful adjunct in the treatment of serious fungal infections. Expand
Candidal Endocarditis Presenting with Bilateral Lower Limb Ischemia
TLDR
A 41-year-old female complaining of acute onset of pain with numbness and tingling in both lower extremities is described, illustrating an unusual presentation of candidal endocarditis with discussion of disease epidemiology, pathogenesis, diagnosis, and treatment. Expand
Antifungals: Mechanism of Action and Drug Resistance.
TLDR
Considering the limited availability of antifungals in use and the emergence of MDR in fungal infections, there is a continuous need for the development of novel broad spectrum antIFungal drugs with better efficacy. Expand
Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009).
TLDR
Although the antifungal activity of numerous compounds has been examined, most of them are at the in vitro or animal models of efficacy stages, therefore, further investigation should be carried out to realize the true clinical utility of these compounds. Expand
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