Activities against Streptococcus pneumoniae of amoxicillin and cefotaxime at physiological concentrations: in vitro pharmacodynamic simulation.

Abstract

An in vitro model simulating amoxicillin and cefotaxime concentrations in human serum (after standard doses) was used to explore the activities of these drugs over time against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae strains. An initial inoculum reduction percentage of > or = 90% was obtained with amoxicillin and maintained… (More)

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@article{Balcabao1996ActivitiesAS, title={Activities against Streptococcus pneumoniae of amoxicillin and cefotaxime at physiological concentrations: in vitro pharmacodynamic simulation.}, author={I P Balcabao and Lorenzo Aguilar and Mary St. Martin and Yuri Garc{\'i}a and Rafael Dal-R{\'e} and Jos{\'e} Pedro Prieto}, journal={Antimicrobial agents and chemotherapy}, year={1996}, volume={40 12}, pages={2904-6} }