Activité antiinflammatoire deZygophyllum gaetulum

  title={Activit{\'e} antiinflammatoire deZygophyllum gaetulum},
  author={Youssef Khabbal and Mina Ait El Cadi and Katim Alaoui and Mg. A. Faouzi and Yahia Cherrah},
RésuméZygophyllumgaetulum Emberger & Maire est un sous-arbrisseau des steppes désertiques du sud du Maroc. Utilisé traditionnellement comme anti-inflammatoire antidiabétique et antispasmodique, il est proposé dans la présente étude d’en évaluer et d’en confirmer l’activité anti-inflammatoire chez l’animal. L’extrait a été préparé selon les méthodes traditionnelles, l’étude a été réalisée sur des rats Wistar des deux sexes âgés de 2 à 3 mois et pesant 200–300 grammes. Le lot essai trait… 
8 Citations

Activité antidiarrhéique de Zygophyllum gaetulum

In Morocco, traditional medicine describes several plants in the treatment of digestive disorders such as diarrhoea, including Zygophyllum gaetulum, used traditionally as an antiinflammatory, antidiabetic, antispasmodic and antidiarrhoeal drug, which is proposed in the present study to evaluate and to confirm its anti-diarrhoea activity in animals.

Effects of Zygophyllum gaetulum Aqueous Extract on Erythrocytes Lipid Peroxidation and Paraoxonase 1 Activity in Hypercholesterolemic Rats

In the hypercholesterolemic rat, the treatment with Z. gaetulum extract induced a cholesterol-lowering effect but didn’t improve erythrocytes lipid peroxidation despite stimulation of antioxidant enzymes activities, suggesting a possible lipoprotein protection from oxidation.

Chemical Composition of Essential Oils and Mineral Contents of Zygophyllum gaetulum (Emb. and Maire)

Abstract Essential oils were obtained by hydrodistillation of Zygophyllum gaetulum collected from Taguounite (south of Morocco). The chemical profiles of essential oils were evaluated by means of



Antiinflammatory activity of some extracts from plants used in the traditional medicine of North‐African countries (II)

The results support the traditional uses for these plants but indicate that the active principles in the chloroform extracts are probably more active and/or are contained in larger concentrations than the principles inThe polar extracts used in the traditional medicine of North‐African countries.

Saponins from Zygophyllum gaetulum.

Three new bisdesmosidic triterpene saponins, zygophylosides I, L and M, and three known quinovic acid glycosides were isolated from Zygophyllum gaetulum by use of 1D and 2D NMR techniques.

Mediators of the inflammation induced in the rat paw by carrageenin

It was concluded that kinins and 5‐HT contributed significantly to oedema formation during this period, and mepyramine and methysergide, at the doses used in the carrageenin experiments, completely antagonized histamine and5‐HT, respectively, and did not affect the skin responses of bradykinin.

Screens for anti‐inflammatory drugs

British Pharmacopoeia (1963). Addendum (1966). London : Pharmaceutical Press. BROOKS, S. A., DAVIES, J. W. L., GRABER, I. G. & RICKETTS, C. R. (1960) Nature, Lond., 188,675676. Handbook of

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

  • K. SeibertY. Zhang P. Isakson
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
In an animal model of acute inflammation, a selective inhibitor of COX-2 inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity.

Biphasic development of carrageenin edema in rats.

The discovery that carrageenin was charred by heat treatment at 130°C for 16 hr, it elicited the full first phase edema volume without subsequent development of the second phase indicates that the secondphase is not a consequence of processes initiated during the first phase but is dependent on the structural integrity of the irritant molecule.

The antipyretic activity of some Moroccan medicinal plants

The antipyretic activity of different extracts from Calotropis procera, Cotula cinerea and Zygophyllum gaetulum was investigated experimentally in rats and was comparable to that of acetylsalicylic acid used as the standard drug.

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.