Activin signaling balances proliferation and differentiation of ovarian niche precursors and enables adjustment of niche numbers.

Abstract

How the numbers of niches and resident stem cells within a particular organ are determined during development and how they may be modulated or corrected is a question with significant medical implications. In the larval ovary of Drosophila melanogaster, somatic precursors for niches, and germ cells that will become germline stem cells, co-develop. Somatic… (More)
DOI: 10.1242/dev.113902

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