Activin regulates estrogen receptor gene expression in the mouse ovary.

  title={Activin regulates estrogen receptor gene expression in the mouse ovary.},
  author={Jingjing L. Kipp and Signe M. Kilen and Teresa K. Woodruff and Kelly E. Mayo},
  journal={The Journal of biological chemistry},
  volume={282 50},
Activin, a member of the transforming growth factor-beta superfamily, is an important modulator of follicle-stimulating hormone synthesis and secretion in the pituitary and plays autocrine/paracrine roles in the regulation of ovarian follicle development. From a microarray study on mouse ovarian granulosa cells, we discovered that the estrogen receptor beta (ERbeta) is inducible by activin. We previously demonstrated that estrogen suppresses activin gene expression, suggesting a feedback… CONTINUE READING


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