Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner.

@article{Guise2006ActivinIT,
  title={Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner.},
  author={Chantal de Guise and Annie Lacerte and Shahrzad Rafiei and Rachel Reynaud and M{\'e}lanie Roy and Thierry Brue and J L Lebrun},
  journal={Endocrinology},
  year={2006},
  volume={147 9},
  pages={4351-62}
}
The pituitary transcription factor Pit-1 regulates hormonal production from the anterior pituitary gland. However, the mechanisms by which Pit-1 gene expression is regulated in humans are poorly understood. Activin, a member of the TGFbeta superfamily, acts as a negative regulator of cell growth and prolactin gene expression in lactotrope cells. In this study, we show that activin negatively regulates the human Pit-1 gene promoter. We defined a 117-bp element within the Pit-1 promoter that is… CONTINUE READING

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