Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.

@article{Mellor2003ActivinBH,
  title={Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.},
  author={Sally L Mellor and Emma M A Ball and Anne E O'Connor and J F Ethier and Mark Cranfield and Jacqueline Schmitt and David J. Phillips and Nigel Patrick Groome and Gail P Risbridger},
  journal={Endocrinology},
  year={2003},
  volume={144 10},
  pages={4410-9}
}
Activins are formed by dimerization of beta-subunits and, as members of the TGF-beta superfamily, have diverse roles as potent growth and differentiation factors. As the biological function of the activin C homodimer (betaC-betaC) is unknown, we sought to compare activin A (betaA-betaA), B (betaB-betaB), and C homodimer bioactivities and to investigate the consequences of activin betaC-subunit overexpression in prostate tumor cells. Exogenous activin A and B homodimers inhibited cell growth and… CONTINUE READING

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