Activin-Like Kinase 2 Functions in Peri-implantation Uterine Signaling in Mice and Humans

@inproceedings{Clementi2013ActivinLikeK2,
  title={Activin-Like Kinase 2 Functions in Peri-implantation Uterine Signaling in Mice and Humans},
  author={Caterina Clementi and Swamy Krishna Tripurani and Michael J. Large and Mark A. Edson and Chad J Creighton and Shannon M Hawkins and Ertuğ Kovanci and Vesa M Kaartinen and John P Lydon and Stephanie A. Pangas and Francesco J DeMayo and Martin M. Matzuk},
  booktitle={PLoS genetics},
  year={2013}
}
Implantation of a blastocyst in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the uterus of pregnant mice, and BMP2 has been shown to be a key regulator of implantation. In this study, we investigated the roles of the BMP type 1 receptor, activin-like kinase 2 (ALK2), during mouse pregnancy by producing mice carrying a… CONTINUE READING
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