Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors.

@article{Sugatani2003ActivinAS,
  title={Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors.},
  author={Toshifumi Sugatani and Ulises M. {\'A}lvarez and Keith A. Hruska},
  journal={Journal of cellular biochemistry},
  year={2003},
  volume={90 1},
  pages={59-67}
}
Recent studies have reported that activin A enhances osteoclastogenesis in cultures of mouse bone marrow cells stimulated with receptor activator of nuclear factor-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). However, the exact mechanisms by which activin A functions during osteoclastogenesis are not clear. RANKL stimulation of… CONTINUE READING