Activin A inhibits activities of lipopolysaccharide-activated macrophages via TLR4, not of TLR2.

@article{Li2013ActivinAI,
  title={Activin A inhibits activities of lipopolysaccharide-activated macrophages via TLR4, not of TLR2.},
  author={Nan Li and Xueling Cui and Jingyan Ge and Jiru Li and Liman Niu and Haiyan Liu and Yan Qi and Zhonghui Liu and Yinan Wang},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={435 2},
  pages={222-8}
}
Activin A, a member of TGF-β superfamily, is involved in either pro-inflammatory or anti-inflammatory responses. Our previous studies have reported that lipopolysaccharide (LPS) can simulate activin A secretion from macrophage, and activin A can induce rest macrophage activation in mice, but inhibit the activities of the activated macrophages. However, the relationship of activin and LPS actions and their mechanism are not well characterized. In the present study, the results showed that both… CONTINUE READING