Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease

  title={Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease},
  author={Maria Semitekolou and Themis Alissafi and Maria Aggelakopoulou and Evangelia Kourepini and Harsha H. Kariyawasam and Antony B. Kay and D Robinson and Clare M Lloyd and Vily Panoutsakopoulou and Georgina Xanthou},
  booktitle={The Journal of experimental medicine},
Activin-A is a pleiotropic cytokine that participates in developmental, inflammatory, and tissue repair processes. Still, its effects on T helper (Th) cell-mediated immunity, critical for allergic and autoimmune diseases, are elusive. We provide evidence that endogenously produced activin-A suppresses antigen-specific Th2 responses and protects against airway hyperresponsiveness and allergic airway disease in mice. Importantly, we reveal that activin-A exerts suppressive function through… CONTINUE READING


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