Activin A induces apoptosis of mouse myeloma cells via the mitochondrial pathway.

@article{Zhang2018ActivinAI,
  title={Activin A induces apoptosis of mouse myeloma cells via the mitochondrial pathway.},
  author={Yuanyi Zhang and Yan Qi and Yang Zhao and Hongyan Sun and Jingyan Ge and Zhonghui Liu},
  journal={Oncology letters},
  year={2018},
  volume={15 2},
  pages={2590-2594}
}
Activin A is a pleiotropic cytokine belonging to the transforming growth factor β superfamily. Abnormal expression of activin A is associated with tumorigenesis. Multiple myeloma is characterized by the development of osteolytic disease, which ultimately leads to cachexia. However, the involvement of activin A in myeloma cell viability and apoptosis remains… CONTINUE READING