Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells.

@article{Ashida2017ActivinAI,
  title={Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells.},
  author={Yuhei Ashida and May Nakajima-Koyama and Akira Hirota and Takuya Yamamoto and Eisuke Nishida},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2017},
  volume={22 2},
  pages={189-202}
}
The Activin/Nodal/TGF-β signaling pathway plays a major role in maintaining mouse epiblast stem cells (EpiSCs). The EpiSC-maintaining medium, which contains Activin A and bFGF, induces differentiation of mouse embryonic stem cells (ESCs) to EpiSCs. Here, we show that Activin A also has an ability to efficiently propagate ESCs without differentiation to… CONTINUE READING
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