Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143.

AIMS Enhanced activin A release from epicardial adipose tissue (EAT) has been linked to the development of cardiac dysfunction in type 2 diabetes (T2D). This study examined whether the inhibition of insulin action induced by epicardial adipokines in cardiomyocytes can be ascribed to alterations in miRNA expression. METHODS AND RESULTS Expression levels of… CONTINUE READING