Activin A and activin receptors in thyroid cancer.

  title={Activin A and activin receptors in thyroid cancer.},
  author={K Marche' Schulte and Christina Jonas and Rainer Krebs and H. D. R{\"o}her},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={11 1},
Proliferation is controlled by a network of mitogenic and growth inhibitory factors. Transforming growth factor-beta1 (TGF-beta1) and activin A are the most important growth inhibitors of benign follicular epithelial cells of the human thyroid. The effects of these substances on malignant primary thyrocytes are not known. We have examined the growth regulatory effects of activin A and TGF-beta1 in primary cultures derived from four papillary cancers, two follicular thyroid cancers, and three… CONTINUE READING


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