Activin A and Follistatin in Menstrual Blood: Low Concentrations in Women With Dysfunctional Uterine Bleeding

@article{Reis2007ActivinAA,
  title={Activin A and Follistatin in Menstrual Blood: Low Concentrations in Women With Dysfunctional Uterine Bleeding},
  author={Fernando M. Reis and Livia Luz de Souza Nascimento and Anastasia Tsigkou and M{\'a}rcia Cristina França Ferreira and Stefano Vincenzo Luisi and Felice Petraglia},
  journal={Reproductive Sciences},
  year={2007},
  volume={14},
  pages={383 - 389}
}
Activin A and follistatin are growth factors produced by several organs, comprising the endometrium, where they modulate cell and tissue differentiation. In this study, the authors tested whether activin A and follistatin are measurable in menstrual blood and whether their concentrations change in women with dysfunctional uterine bleeding (DUB). The authors evaluated healthy women with regular menstrual cycles (n = 15) and women with DUB (n = 12). Activin A and follistatin were measured in both… Expand
Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis.
TLDR
It is demonstrated that serum activin A and follistatin are not significantly altered in peritoneal or deep infiltrating endometriosis and have limited diagnostic accuracy in the diagnosis of ovarian endometRIoma. Expand
High serum follistatin levels in women with ovarian endometriosis.
TLDR
Serum follistatin is increased in women with endometriosis and allows clear distinction between endometioma and other benign ovarian cysts, and has the sensitivity and specificity to become a useful clinical marker of ovarianendometrioma. Expand
Apoptosis modulation by activin A and follistatin in human endometrial stromal cells
  • L. M. Coutinho, É. Vieira, +4 authors F. Reis
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2016
TLDR
Findings indicate that activin A promotes HESC survival, possibly by a TNF-independent pathway, and this mechanism may be critical to the actions ofactivin A upon stromal cell growth and differentiation in physiology and disease. Expand
Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination.
TLDR
Activin A is secreted into uterine lumen; the levels in endometrial washing fluids were higher in women who subsequently became pregnant after IUI, so its measurement may be useful in predicting successful implantation. Expand
Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis.
TLDR
Findings point to the existence of an increased local inflammatory activity in women with endometriosis. Expand
Embryo Implantation and Inhibin Dimers (Activin) as Diagnosis of Ectopic Pregnancy
TLDR
The local derangement of activin A pathway in some pregnancy disorders (incomplete and complete miscarriages, recurrent abortion, and ectopic pregnancy [EP]) further sustains the hypothesis thatactivin A and its related proteins play a relevant role in the formation of pregnancy. Expand
Evaluation of endometrial urocortin secretion for prediction of pregnancy after intrauterine insemination.
TLDR
The data suggest that the probability of having a successful pregnancy-producing IUI may be better estimated by measuring urocortin in endometrial wash fluid, and its concentrations before IUI are higher in women who subsequently achieve pregnancy. Expand
A new role for activin in endometrial repair after menses.
TLDR
A functional role for activin is demonstrated for the first time in endometrial repair after menses in animals transgenically induced to overexpress activin's natural inhibitor, follistatin. Expand
Activin and inhibin signaling: From regulation of physiology to involvement in the pathology of the female reproductive system.
TLDR
The up-to-date evidence indicates that these cytokines regulate germ cell development, follicular development, ovulation, uterine receptivity, decidualization and placentation through the activation of several signaling pathways and that their dysregulated expression is involved in the pathogenesis and pathophysiology of the numerous diseases, including pregnancy complications, that disturb reproduction. Expand
Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive Immuno PCR
TLDR
It is demonstrated that moderate training does not affect the concentrations of MYOPRO to FOLLI and androgen treatment results in a significant increase of Myostatin propeptide in skeletal muscle and serum. Expand
...
1
2
...

References

SHOWING 1-10 OF 39 REFERENCES
Endometrial Expression and Secretion of Activin A, But Not Follistatin, Increase in the Secretory Phase of the Menstrual Cycle
TLDR
Both Activin A and follistatin mRNAs are expressed by human endometrium; however, activin A but not follistati peptide expression and secretion were increased in the secretory phase of the menstrual cycle, suggesting an important role in human endometricrium. Expand
Healthy women and patients with endometriosis show high concentrations of inhibin A, inhibin B, and activin A in peritoneal fluid throughout the menstrual cycle.
TLDR
The findings that high concentrations of inhibin A and B are present in peritoneal fluid and that menstrual cycle-related changes occur suggest that reproductive organs may contribute to inhibin-related proteins in peritonal fluid. Expand
Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis.
TLDR
Evidence is provided for a local production and secretion of inhibin A and activin A in ovarian endometriotic cysts and immunoreactive alpha and betaA subunits were strongly expressed both in the epithelial and stromal components of ovarianendometrioma. Expand
Role of activin A as a mediator of in vitro endometrial stromal cell decidualization via the cyclic adenosine monophosphate pathway.
TLDR
The role of activin A in regulating endometrial stromal decidualization and its known promotion of the invasive phenotype of the trophoblast suggest unique autocrine and paracrine interactions at the maternal/fetal interface during implantation, which might have important clinical implications for the understanding and treatment of fertility and pregnancy disorders. Expand
Expression and secretion of activin A: possible physiological and clinical implications.
TLDR
The present review summarizes the various activin sources and functions in humans, and the data obtained on activin A measurement in various biological uids which suggest possible physiological and clinical implications. Expand
Expression of activin receptors, follistatin and betaglycan by human endometrial stromal cells; consistent with a role for activins during decidualization.
TLDR
It is shown that stromal cells are capable of responding to activin, and that there is tight local regulation of activin action within the endometrium, as activin production is up-regulated in decidual cells. Expand
Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception.
TLDR
Endometrial expression of inhibin alpha, ssA and ssB subunits was examined by immunohistochemistry and in-situ hybridization, across the menstrual cycle and in early pregnancy, finding all three subunits found to be expressed in endometrium. Expand
Characterization of unique binding kinetics of follistatin and activin or inhibin in serum.
Serum binding proteins (BPs) have been identified for several peptide and protein hormones, and their presence has significant implications for the biological action of the hormone. Follistatin (FS)Expand
Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome.
TLDR
Patients with RPL have distinct endometrial gene expression profiles depending on the presence or absence of circulating aPL antibodies, which may compromise implantation and predispose to complement-mediated pregnancy failure. Expand
Potential roles for endometrial inhibins, activins and follistatin during human embryo implantation and early pregnancy
TLDR
Evidence is presented for integral roles for the inhibin and activin family in the paracrine regulation of endometrial receptivity, decidualization and implantation. Expand
...
1
2
3
4
...