Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells.

@article{Kim2013ActivinAE,
  title={Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells.},
  author={Hyo-Sup Kim and S Hong and S M Oh and Jae-Hyeon Kim and M V Lee and Moon-Kyu Lee},
  journal={The Journal of endocrinology},
  year={2013},
  volume={217 3},
  pages={241-52}
}
Islet transplantation is one treatment option for diabetes mellitus. However, novel sources of pancreatic islets or insulin-producing cells are required because the amount of donor tissue available is severely limited. Pancreatic ductal cells are an alternative source of β-cells because they have the potential to differentiate into insulin-producing cells. We investigated whether treatment of human pancreatic ductal cells with activin A (ActA) and exendin-4 (EX-4) stimulated… CONTINUE READING
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