Activin/Nodal Signaling Supports Retinal Progenitor Specification in a Narrow Time Window during Pluripotent Stem Cell Neuralization

@inproceedings{Bertacchi2015ActivinNodalSS,
  title={Activin/Nodal Signaling Supports Retinal Progenitor Specification in a Narrow Time Window during Pluripotent Stem Cell Neuralization},
  author={Michele Bertacchi and Giuseppe Lupo and Luca Pandolfini and S. Casarosa and Mara D’Onofrio and Roger A. Pedersen and William A. Harris and Federico Cremisi},
  booktitle={Stem cell reports},
  year={2015}
}
Retinal progenitors are initially found in the anterior neural plate region known as the eye field, whereas neighboring areas undertake telencephalic or hypothalamic development. Eye field cells become specified by switching on a network of eye field transcription factors, but the extracellular cues activating this network remain unclear. In this study, we used chemically defined media to induce in vitro differentiation of mouse embryonic stem cells (ESCs) toward eye field fates. Inhibition of… CONTINUE READING

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