Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection.

@article{Huang2013ActivelyTV,
  title={Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection.},
  author={Min A. Huang and Betty C. Galarreta and Arif E. Cetin and Hatice Altug},
  journal={Lab on a chip},
  year={2013},
  volume={13 24},
  pages={
          4841-7
        }
}
Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery efficiency and ultrafast sensor response, as compared to conventional fluidic systems. 70 nm sized virus like analyte solution is used to experimentally demonstrate the system performance improvements. Sensor response time is reduced by one order of… 
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References

SHOWING 1-10 OF 55 REFERENCES
An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media.
TLDR
A label-free optofluidic nanoplasmonic sensor that can directly detect intact viruses from biological media at clinically relevant concentrations with little to no sample preparation is demonstrated.
Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes
Performances of the biosensors are often limited by the depletion zones created around the sensing area which impede the effective analyte transport. To overcome this limitation, we propose and
Label-free biomarker sensing in undiluted serum with suspended microchannel resonators.
TLDR
It is demonstrated that carboxybetaine-derived polymers developed to adsorb directly onto SMR SiO(2) surfaces act as ultralow fouling and functionalizable surface coatings and enables detection of activated leukocyte cell adhesion molecule (ALCAM) in undiluted serum with a limit of detection of 10 ng/mL.
Sub-wavelength nanofluidics in photonic crystal sensors.
TLDR
A novel sensor scheme combining nano-photonics and nano-fluidics on a single platform through the use of free-standing photonic crystals is introduced and it is theoretically and experimentally demonstrated that both fluidics and light can be manipulated at sub-wavelength scales.
Numerical characterization and optimization of the microfluidics for nanowire biosensors.
The present study aims to enhance the analyte transport to the surface of nanowires (NWs) through optimizing the sensing configuration and the flow patterns inside the microfluidic channel, and hence
Plasmonic nanorod metamaterials for biosensing.
TLDR
This work demonstrates an improvement in biosensing technology using a plasmonic metamaterial that is capable of supporting a guided mode in a porous nanorod layer and provides an enhanced sensitivity to refractive-index variations of the medium between the rods.
Detection limits for nanoscale biosensors.
TLDR
The calculations reveal that reported femtomolar detection limits for biomolecular assays are very likely an analyte transport limitation, not a signal transduction limitation.
On-chip surface-based detection with nanohole arrays.
TLDR
Results indicate the efficacy of nanohole arrays as surface plasmon-based sensing elements in a microfluidic platform, adding unique surface-sensitive diagnostic capabilities to the existing suite of microfluidsic-based analytical tools.
...
1
2
3
4
5
...