Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway.

@article{Obregon2009ActiveUO,
  title={Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway.},
  author={Carolina Obregon and Barbara Rothen-Rutishauser and Peter Gerber and Peter Gehr and Laurent Pierre Nicod},
  journal={The American journal of pathology},
  year={2009},
  volume={175 2},
  pages={696-705}
}
Dendritic cells (DCs) can release hundreds of membrane vesicles, called exovesicles, which are able to activate resting DCs and distribute antigen. Here, we examined the role of mature DC-derived exovesicles in innate and adaptive immunity, in particular their capacity to activate epithelial cells. Our analysis of exovesicle contents showed that exovesicles contain major histocompatibility complex-II, CD40, and CD83 molecules in addition to tumor necrosis factor (TNF) receptors, TNFRI and… CONTINUE READING
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