Active turnover modulates mature microRNA activity in Caenorhabditis elegans

@article{Chatterjee2009ActiveTM,
  title={Active turnover modulates mature microRNA activity in Caenorhabditis elegans},
  author={S. Chatterjee and H. Grosshans},
  journal={Nature},
  year={2009},
  volume={461},
  pages={546-549}
}
  • S. Chatterjee, H. Grosshans
  • Published 2009
  • Medicine, Biology
  • Nature
  • MicroRNAs (miRNAs) constitute a large class of regulatory RNAs that repress target messenger RNAs to control various biological processes. Accordingly, miRNA biogenesis is highly regulated, controlled at both transcriptional and post-transcriptional levels, and overexpression and underexpression of miRNAs are linked to various human diseases, particularly cancers. As RNA concentrations are generally a function of biogenesis and turnover, active miRNA degradation might also modulate miRNA… CONTINUE READING
    microRNA Biogenesis and its Impact on RNA Interference
    • 1
    Differential regulation of microRNA stability.
    • 249
    • Highly Influenced
    • PDF

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