Active transport at the blood-CSF barrier contributes to manganese influx into the brain.

@article{Schmitt2011ActiveTA,
  title={Active transport at the blood-CSF barrier contributes to manganese influx into the brain.},
  author={Charlotte C. Schmitt and Nathalie Strazielle and Pierre M. Richaud and Alexandre Bouron and Jean-François Ghersi-Egea},
  journal={Journal of neurochemistry},
  year={2011},
  volume={117 4},
  pages={747-56}
}
Manganese is an essential trace element, and a contrast agent of potential interest for brain magnetic resonance imaging. Brain overexposure to manganese, however induces a neurodegenerative syndrome. Imaging data suggest that manganese appearance into the CSF precedes its accumulation into the cerebral parenchyma. We therefore investigated manganese uptake and transport at the blood-CSF barrier. Like lead, the non protein-bound divalent manganese accumulated into the rat choroid plexus. The… CONTINUE READING

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