Active stress kinases in proliferating endothelial cells associated with cytoskeletal structures.

@article{Hamel2006ActiveSK,
  title={Active stress kinases in proliferating endothelial cells associated with cytoskeletal structures.},
  author={Marianne Hamel and Daniela Kanyi and Mark D. Cipolle and Linda J. Lowe-Krentz},
  journal={Endothelium : journal of endothelial cell research},
  year={2006},
  volume={13 3},
  pages={
          157-70
        }
}
It has become increasingly clear that stress-activated protein kinases have cytoplasmic substrates in addition to well-established transcription factor substrates in cell nuclei. The present study documented specific cytoplasmic locations of these enzymes in proliferating vascular cells. Immunofluorescent staining for active c-jun NH2-terminal kinase (JNK), the precipitation of JNK with microfilaments, and the loss of fiber-associated active JNK after cytochalasin treatment, but not nocodazole… CONTINUE READING

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