Active site residues of cephalosporin acylase are critical not only for enzymatic catalysis but also for post-translational modification.

@article{Kim2001ActiveSR,
  title={Active site residues of cephalosporin acylase are critical not only for enzymatic catalysis but also for post-translational modification.},
  author={Seung-Hyun Kim and Young Sil Kim},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 51},
  pages={48376-81}
}
Cephalosporin acylase (CA) is a recently identified N-terminal hydrolase. It is also a commercially important enzyme in producing 7-aminocephalosporanic acid (7-ACA), a backbone chemical in synthesizing semi-synthetic cephalosporin antibiotics. CA is translated as an inactive single chain precursor, being post-translationally modified into an active enzyme… CONTINUE READING