Active site proton delivery and the lyase activity of human CYP17A1.

@article{Khatri2014ActiveSP,
  title={Active site proton delivery and the lyase activity of human CYP17A1.},
  author={Yogan Khatri and Michael C. Gregory and Yelena V. Grinkova and Ilia G Denisov and Stephen G Sligar},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={443 1},
  pages={
          179-84
        }
}
  • Yogan Khatri, Michael C. Gregory, +2 authors Stephen G Sligar
  • Published 2014
  • Medicine, Chemistry
  • Biochemical and biophysical research communications
  • Cytochrome P450 CYP17A1 catalyzes a series of reactions that lie at the intersection of corticoid and androgen biosynthesis and thus occupies an essential role in steroid hormone metabolism. This multifunctional enzyme catalyzes the 17α-hydroxylation of Δ4- and Δ5-steroids progesterone and pregnenolone to form the corresponding 17α-hydroxy products through its hydroxylase activity, and a subsequent 17,20-carbon-carbon scission of pregnene-side chain produce the androgens androstenedione (AD… CONTINUE READING

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