Structural insights into the function of steroidogenic cytochrome P450 17A1.
- Rahul Yadav, Elyse M Petrunak, D Fernando Estrada, Emily E Scott
- Molecular and cellular endocrinology
- 2017
Highly Influenced
4 Excerpts
Active site proton delivery and the lyase activity of human CYP17A1.
- Published 2014 in Biochemical and biophysical research…
Abstract
Cytochrome P450 CYP17A1 catalyzes a series of reactions that lie at the intersection of corticoid and androgen biosynthesis and thus occupies an essential role in steroid hormone metabolism. This multifunctional enzyme catalyzes the 17α-hydroxylation of Δ4- and Δ5-steroids progesterone and pregnenolone to form the corresponding 17α-hydroxy products through… (More)
Topics
- Steroid 17-alpha-Hydroxylase
- dehydroepiandrosterone
- Progesterone
- Steroids
- Lyase
- lyase activity
- Pregnenes
- Ethanol
- Pregnenolone
- NADP
- Adrenal Cortex Hormones
- Protons
- pyridine nucleotide
- Catalysis
- Androgens
- Nucleotides
- Cytochrome P450
- Iron
- Wild Type
- Hydroxylation
- Oxidation-Reduction
- hormone metabolism
- Cytochromes
- Androstenedione
- Efficiency