Active site modification of factor VIIa affects interactions of the protease domain with tissue factor.

Abstract

In the initiation of coagulation, tissue factor (TF) allosterically activates the serine protease factor VIIa (VIIa) through specific interactions with protease domain residues. These interactions, and consequently affinity for TF, may be influenced by conformational changes in the protease domain that result from zymogen-enzyme transition or occupancy of… (More)

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Cite this paper

@article{Dickinson1997ActiveSM, title={Active site modification of factor VIIa affects interactions of the protease domain with tissue factor.}, author={C. D. Dickinson and Wolfram Ruf}, journal={The Journal of biological chemistry}, year={1997}, volume={272 32}, pages={19875-9} }