Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis.

@article{AlDabbagh2008ActiveSM,
  title={Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis.},
  author={Bayan Al-Dabbagh and Xavier Henry and Meriem El Ghachi and Genevi{\`e}ve Auger and Didier Blanot and Claudine Parquet and Dominique Mengin-Lecreulx and Ahmed Bouhss},
  journal={Biochemistry},
  year={2008},
  volume={47 34},
  pages={8919-28}
}
The MraY transferase is an integral membrane protein that catalyzes an essential step of peptidoglycan biosynthesis, namely the transfer of the phospho-N-acetylmuramoyl-pentapeptide motif onto the undecaprenyl phosphate carrier lipid. It belongs to a large superfamily of eukaryotic and prokaryotic prenyl sugar transferases. No 3D structure has been reported for any member of this superfamily, and to date MraY is the only protein that has been successfully purified to homogeneity. Nineteen polar… CONTINUE READING

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