Active site mapping of Loxosceles phospholipases D: Biochemical and biological features.


Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal failure. The catalytic (H12 and H47) and metal-ion binding (E32 and D34) residues in Loxosceles intermedia phospholipase D (LiRecDT1) were… (More)
DOI: 10.1016/j.bbalip.2016.05.009