Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.

@article{Krishnamurthy2014ActiveSC,
  title={Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.},
  author={Srinath Krishnamurthy and Balakrishnan Shenbaga Moorthy and Lim Xin Xiang and Lim Xin Shan and Kavitha Bharatham and Nikhil Kumar Tulsian and Ivana Mihalek and Ganesh Srinivasan Anand},
  journal={Biophysical journal},
  year={2014},
  volume={107 6},
  pages={
          1426-40
        }
}
Cyclic 3'5' adenosine monophosphate (cAMP)-dependent-protein kinase (PKA) signaling is a fundamental regulatory pathway for mediating cellular responses to hormonal stimuli. The pathway is activated by high-affinity association of cAMP with the regulatory subunit of PKA and signal termination is achieved upon cAMP dissociation from PKA. Although steps in the activation phase are well understood, little is known on how signal termination/resetting occurs. Due to the high affinity of cAMP to PKA… CONTINUE READING
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