Active self-healing encapsulation of vaccine antigens in PLGA microspheres.

@article{Desai2013ActiveSE,
  title={Active self-healing encapsulation of vaccine antigens in PLGA microspheres.},
  author={Kashappa-Goud H. Desai and Steven P Schwendeman},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2013},
  volume={165 1},
  pages={
          62-74
        }
}
Herein, we describe the detailed development of a simple and effective method to microencapsulate vaccine antigens in poly(lactic-co-glycolic acid) (PLGA) by simple mixing of preformed active self-microencapsulating (SM) PLGA microspheres in a low concentration aqueous antigen solution at modest temperature (10-38 °C). Co-encapsulating protein-sorbing vaccine adjuvants and polymer plasticizers were used to "actively" load the protein in the polymer pores and facilitate polymer self-healing at a… CONTINUE READING
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