Active role of chondrocyte apoptosis in endochondral ossification.

  title={Active role of chondrocyte apoptosis in endochondral ossification.},
  author={Gary J. Gibson},
  journal={Microscopy research and technique},
  volume={43 2},
Endochondral ossification involves an ordered progression from cell division through hypertrophic differentiation to cell death. The apoptotic nature of chondrocyte death was first suggested by characteristic changes in morphology; and more recently by the pattern of DNA fragmentation and other characteristic features of apoptosis. In situ detection, although controversial, suggests that DNA fragmentation probably does not occur until late in hypertrophic differentiation. From observations of… CONTINUE READING