Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis.

@article{Overmeyer2008ActiveRT,
  title={Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis.},
  author={Jean H. Overmeyer and Aparna Kaul and Erin E. Johnson and William A Maltese},
  journal={Molecular cancer research : MCR},
  year={2008},
  volume={6 6},
  pages={
          965-77
        }
}
Expression of activated Ras in glioblastoma cells induces accumulation of large phase-lucent cytoplasmic vacuoles, followed by cell death. This was previously described as autophagic cell death. However, unlike autophagosomes, the Ras-induced vacuoles are not bounded by a double membrane and do not sequester organelles or cytoplasm. Moreover, they are not acidic and do not contain the autophagosomal membrane protein LC3-II. Here we show that the vacuoles are enlarged macropinosomes. They… CONTINUE READING

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