Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

@article{Rao1992ActiveOS,
  title={Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.},
  author={G Vamshi Nandan Rao and Bradford C. Berk},
  journal={Circulation research},
  year={1992},
  volume={70 3},
  pages={593-9}
}
Vascular smooth muscle cells (VSMCs) proliferate in response to arterial injury. Recent findings suggest that, in addition to platelet-derived growth factors, growth factors from inflammatory cells and endothelial cells at the site of injury may contribute to VSMC proliferation. We hypothesized that a common mechanism by which endothelial cells and inflammatory cells stimulate VSMC growth could be the active oxygen species (i.e., O2-, H2O2, and .OH) generated during arterial injury. Using… CONTINUE READING
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