Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils.

@article{Humphries2008ActiveNC,
  title={Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils.},
  author={Sally M Humphries and Yinhui Lu and Elizabeth G. Canty and Karl E Kadler},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 18},
  pages={12129-35}
}
It is established fact that type I collagen spontaneously self-assembles in vitro in the absence of cells or other macromolecules. Whether or not this is the situation in vivo was unknown. Recent evidence shows that intracellular cleavage of procollagen (the soluble precursor of collagen) to collagen can occur in embryonic tendon cells in vivo, and when this occurs, intracellular collagen fibrils are observed. A cause-and-effect relationship between intracellular collagen and intracellular… CONTINUE READING

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