Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals.

@article{Tinel1999ActiveMS,
  title={Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals.},
  author={Hanna Tinel and Jos{\'e} Manuel Cancela and Hideo Mogami and Julia V Gerasimenko and Oleg V Gerasimenko and Alexei V Tepikin and Ole H Petersen},
  journal={The EMBO journal},
  year={1999},
  volume={18 18},
  pages={4999-5008}
}
Agonist-evoked cytosolic Ca(2+) spikes in mouse pancreatic acinar cells are specifically initiated in the apical secretory pole and are mostly confined to this region. The role played by mitochondria in this process has been investigated. Using the mitochondria-specific fluorescent dyes MitoTracker Green and Rhodamine 123, these organelles appeared as a bright belt concentrated mainly around the secretory granule area. We tested the effects of two different types of mitochondrial inhibitor on… CONTINUE READING

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Cyclic ADP-ribose

  • P. Thorn, O. Gerasimenko, O. H. Petersen
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