Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure.

@article{Klein2011ActiveMO,
  title={Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure.},
  author={Th{\'e}o Klein and Rainer Bischoff},
  journal={Journal of proteome research},
  year={2011},
  volume={10 1},
  pages={17-33}
}
The "a disintegrin and metalloproteases" (ADAMs) are membrane-anchored metzincins of the adamalysin subfamily. This review gives an overview over the biological function and structure of ADAMs focusing on members of the family that display proteolytic activity. ADAMs are involved in a range of human diseases such as cancer metastasis, inflammatory disorders, neurological disease or asthma. It is, however, often difficult to assign a definitive role to a specific member of the ADAM family in a… CONTINUE READING

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