Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes.

@article{Laczk2007ActiveLO,
  title={Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes.},
  author={Roz{\'a}lia Laczk{\'o} and Korn{\'e}lia Moln{\'a}rn{\'e} Szauter and Matthias K. Jansen and P{\'e}ter Holl{\'o}si and Marianna Mur{\'a}nyi and Jakob Molnar and Keith S K Fong and Aleksander Hinek and Katalin Csisz{\'a}r},
  journal={Neuropathology and applied neurobiology},
  year={2007},
  volume={33 6},
  pages={631-43}
}
The extracellular matrix (ECM) plays a critical role during the development and invasion of primary brain tumours. However, the function of ECM components and signalling between a permissive ECM and invasive astrocytes is not fully understood. We have recently reported the ECM enzyme, lysyl oxidase (LOX), in the central nervous system and observed up-regulation of LOX in anaplastic astrocytoma cells. While the catalytic function of LOX is essential for cross-linking of ECM proteins, we also… CONTINUE READING

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