Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.

@article{Brangwynne2011ActiveLB,
  title={Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.},
  author={Clifford P Brangwynne and Timothy J Mitchison and Anthony A. Hyman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 11},
  pages={4334-9}
}
For most intracellular structures with larger than molecular dimensions, little is known about the connection between underlying molecular activities and higher order organization such as size and shape. Here, we show that both the size and shape of the amphibian oocyte nucleolus ultimately arise because nucleoli behave as liquid-like droplets of RNA and protein, exhibiting characteristic viscous fluid dynamics even on timescales of < 1 min. We use these dynamics to determine an apparent… CONTINUE READING
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