Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer

@article{Montero2014ActiveKP,
  title={Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer},
  author={Juan Carlos Montero and Azucena Espar{\'i}s-Ogando and Mar{\'i}a Florencia Re-Louhau and Susana Rossi Seoane and Mojgan Ojaghzadeh Khalil Abad and Raul Calero and A. P{\'e}rez Oca{\~n}a and Atanasio Pandiella},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={148-156}
}
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer. Despite response to chemotherapy, relapses are frequent and resistance to available treatments is often seen in the metastatic setting. Therefore, identification of new therapeutic targets is required. With this aim, we have profiled the activation status of 44 receptor tyrosine kinases (RTKs) and their major signaling pathways in patient-derived TNBC tumors. Frequent co-activation of several RTKs as well as the… CONTINUE READING
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