Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k.

  title={Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k.},
  author={B. Benn and D. Ajibade and A. Porta and P. Dhawan and M. Hediger and J. Peng and Y. Jiang and G. T. Oh and E. Jeung and L. Lieben and R. Bouillon and G. Carmeliet and S. Christakos},
  volume={149 6},
  • B. Benn, D. Ajibade, +10 authors S. Christakos
  • Published 2008
  • Chemistry, Medicine
  • Endocrinology
  • To study the role of the epithelial calcium channel transient receptor potential vanilloid type 6 (TRPV6) and the calcium-binding protein calbindin-D9k in intestinal calcium absorption, TRPV6 knockout (KO), calbindin-D9k KO, and TRPV6/calbindin-D(9k) double-KO (DKO) mice were generated. TRPV6 KO, calbindin-D9k KO, and TRPV6/calbindin-D9k DKO mice have serum calcium levels similar to those of wild-type (WT) mice ( approximately 10 mg Ca2+/dl). In the TRPV6 KO and the DKO mice, however, there is… CONTINUE READING
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