Active induction of experimental allergic encephalomyelitis

@article{Stromnes2006ActiveIO,
  title={Active induction of experimental allergic encephalomyelitis},
  author={Ingunn M. Stromnes and Joan M. Goverman},
  journal={Nature Protocols},
  year={2006},
  volume={1},
  pages={1810-1819}
}
This protocol details a method to actively induce experimental allergic encephalomyelitis (EAE), a widely used animal model for studies of multiple sclerosis. EAE is induced by stimulating T-cell-mediated immunity to myelin antigens. Active induction of EAE is accomplished by immunization with myelin antigens emulsified in adjuvant. This protocol focuses on induction of EAE in mice; however, the same principles apply to EAE induction in other species. EAE in rodents is manifested typically as… CONTINUE READING
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