Active in vitro reduction of antigen presenting cells in human corneal grafts using different chemokines.

@article{Irschick2010ActiveIV,
  title={Active in vitro reduction of antigen presenting cells in human corneal grafts using different chemokines.},
  author={Ulrike M Irschick and Wolfgang Johann Mayer and Nicole Kranebitter and Nikolaus Romani and Hartwig P. Huemer and Eveline U. Irschick},
  journal={Current eye research},
  year={2010},
  volume={35 2},
  pages={
          176-83
        }
}
BACKGROUND For the fate of a graft the antigen presenting cells play an important role. Chemokines can lead to enhanced migration of these cells. We therefore investigated if fresh human corneas bear the chemokine receptor 7 (CCR7) and if its ligands can force the emigration of dendritic cells in an in vitro model. METHODS We used human corneas excluded for transplantation and performed migration tests using chemokine ligands 19 (CCL19) and 21 (CCL21) or the complement factor 5a (C5a… CONTINUE READING