Active immunization of stumptailed macaque monkeys against luteinizing hormone releasing hormone, and its effects on menstrual cycles, ovarian steroids and positive feedback.

@article{Fraser1983ActiveIO,
  title={Active immunization of stumptailed macaque monkeys against luteinizing hormone releasing hormone, and its effects on menstrual cycles, ovarian steroids and positive feedback.},
  author={Hamish M. Fraser},
  journal={Journal of reproductive immunology},
  year={1983},
  volume={5 3},
  pages={173-83}
}
Five female stumptailed macaque monkeys with regular menstrual cycles were immunized against luteinizing hormone releasing hormone (LHRH) conjugated to tetanus toxoid. The conjugate was given in Freund's complete adjuvant (3 monkeys) or dipeptide adjuvant (2 monkeys). Only the 3 monkeys immunized using Freund's adjuvant produced LHRH antibody titres capable of having effects on menstrual cycles. Elevated levels of LHRH antibody were associated with an absence of preovulatory luteinizing hormone… CONTINUE READING